Emerging viruses represent a major concern for public health offices. Climate changes, the international migration of people and products, deforestation, and other anthropogenic activities (and their consequences) have been historically and continuously related to the emerging and re-emerging of new viruses, triggering an increasing number of notified outbreaks, epidemics, and pandemics. In this very popular Special Issue (Emerging Viruses: Surveillance, Prevention, Evolution, and Control), we are proud to have received a total of 70 manuscript submissions, with an acceptance rate 54.29% (38 papers) from colleagues from different parts of the world, working on a wide range of topics.